Posts Tagged ‘treatment’

New Paper Published on EPM

Friday, January 13th, 2012

A paper has been published on the trial drug Oroquin-10 and the use of the stall-side antibody test strips.  Published in International Journal of Applied Research in Veterinary Medicine.  Rapid diagnosis of EPM has always been an issue.  The UC Davis test takes 7-10 days to get results back, and measures antibodies to protozoa that don’t cause EPM.  The Multiplex strip is specific to Sarcocystis neurona, and is performed at the barn, while the vet is looking at the horse.  The vet can perform a nerological exam, rule out other diseases, AND perform the antibody test while at the horse.  This is a major step forward in diagnostics.  The test packs are available from Prota.

What if….

Saturday, December 17th, 2011

EPM has always been described as a disease of protozoa in the CNS.  The protozoa cause lessions in the CNS when they reproduce.  The lessions interfere with nerve signals, and the horse has limited feeling and awareness of the limbs (or face, jaw, tail).  It has been known for years that inflammation of the CNS plays a large part in lessions and nerve damage.  Anti-inflammatories have always played a part in the treatment for EPM.

"I've never met a Sacrcocyst I didn't want to research."

What if, inflammation plays a much larger role than was previously recognized?  Inflammation may be caused by the toxins produced by Sarcocystis neurona, but what if long, drawn-out EPM symptoms are a manifestation of inflammation, not the protozoa?

Researcher Siobhan Ellison, DVM is looking into this question.  See the November 29th blog here: Pathogenes Research Blog.

 

As Good as it Gets

Monday, October 17th, 2011

In September I posted that I had seen great improvement with Fudge’s cranial symptoms with the preventative dose of decoquinate.  I discussed giving Fudge a treatment of decoquinate to see if it would help with any latent infection.  And the answer is… I have not seen additional improvement with the treatment dose.  I think he is as good as he is going to get.

I know from testing the other horse that my two are getting multiple exposures to Sarcocystis neurona over the course of a year.  There are a lot of opossums in my area, and I see them weekly.  This re-exposure will help keep the IgG antibodies primed in their bodies.  In this case, did a treatment dose of decoquinate help?  I don’t think so, the preventative had already helped his immune system tackle any latent infection.  Did the treatment dose hurt?  I’m not seeing any downside to one treatment dose.  It would not be a good idea to treat repeatedly, thinking he would get better.